Autocrine regulation of tumor cell repopulation by Hsp70-HMGB1 alarmin complex
Abstract Background Cancer recurrence is regulated by a variety of factors, among which is the material of dying tumor cells; it is suggested that remaining after anti-cancer therapy tumor cells receive a signal from proteins called damage-associated molecular patterns (DAMPs), one of which is heat shock protein 70 (Hsp70).Methods Two models of tum